dna methylation data obtained with the goldengate beadarray Search Results


dna methylation data obtained with the goldengate beadarray  (GoldenGate Software Inc)
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GoldenGate Software Inc dna methylation data obtained with the goldengate beadarray
(A) Pearson correlation was used to measure linear relationships between DNA methylation and gene expression levels for 1505 CpG probes represented on the GoldenGate Methylation <t>BeadArray.</t> The panels represent examples of a gene with high (left) and low (right) Pearson correlation coefficients when analyzing DNA methylation levels (x axis) against gene expression levels (y axis). (B) A discretization approach was used to classify samples into methylated (M) or unmethylated (U) groups based on the mean ( μ ) methylation value and standard deviation ( σ ) of a given probe. Statistically significant gene expression differences between M and U groups indicated a methylation-expression correlation for the gene in question.
Dna Methylation Data Obtained With The Goldengate Beadarray, supplied by GoldenGate Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(A) Pearson correlation was used to measure linear relationships between DNA methylation and gene expression levels for 1505 CpG probes represented on the GoldenGate Methylation BeadArray. The panels represent examples of a gene with high (left) and low (right) Pearson correlation coefficients when analyzing DNA methylation levels (x axis) against gene expression levels (y axis). (B) A discretization approach was used to classify samples into methylated (M) or unmethylated (U) groups based on the mean ( μ ) methylation value and standard deviation ( σ ) of a given probe. Statistically significant gene expression differences between M and U groups indicated a methylation-expression correlation for the gene in question.

Journal: PLoS ONE

Article Title: DNA Methylation in Multiple Myeloma Is Weakly Associated with Gene Transcription

doi: 10.1371/journal.pone.0052626

Figure Lengend Snippet: (A) Pearson correlation was used to measure linear relationships between DNA methylation and gene expression levels for 1505 CpG probes represented on the GoldenGate Methylation BeadArray. The panels represent examples of a gene with high (left) and low (right) Pearson correlation coefficients when analyzing DNA methylation levels (x axis) against gene expression levels (y axis). (B) A discretization approach was used to classify samples into methylated (M) or unmethylated (U) groups based on the mean ( μ ) methylation value and standard deviation ( σ ) of a given probe. Statistically significant gene expression differences between M and U groups indicated a methylation-expression correlation for the gene in question.

Article Snippet: For these approaches we used DNA methylation data obtained with the GoldenGate BeadArray technology along with corresponding array-based gene expression data from 193 human MM samples.

Techniques: DNA Methylation Assay, Expressing, Methylation, Standard Deviation

Box plots represent gene expression levels generated by either microarray or qRT-PCR. Data are shown for samples classified as U or M based on the methylation status of p16 (A), DLC1 (B), IGF1R (C), or IL17RB (D). For microarray data, probe intensities are plotted on the y-axis. Relative fold-change differences are plotted for data generated by qRT-PCR. The number of samples in each group is displayed above each plot. The GoldenGate BeadArray probe names are indicated above each pair of box plots.

Journal: PLoS ONE

Article Title: DNA Methylation in Multiple Myeloma Is Weakly Associated with Gene Transcription

doi: 10.1371/journal.pone.0052626

Figure Lengend Snippet: Box plots represent gene expression levels generated by either microarray or qRT-PCR. Data are shown for samples classified as U or M based on the methylation status of p16 (A), DLC1 (B), IGF1R (C), or IL17RB (D). For microarray data, probe intensities are plotted on the y-axis. Relative fold-change differences are plotted for data generated by qRT-PCR. The number of samples in each group is displayed above each plot. The GoldenGate BeadArray probe names are indicated above each pair of box plots.

Article Snippet: For these approaches we used DNA methylation data obtained with the GoldenGate BeadArray technology along with corresponding array-based gene expression data from 193 human MM samples.

Techniques: Expressing, Generated, Microarray, Quantitative RT-PCR, Methylation